Innovation & Application丨HOLVES-Fermenter & Bioreactor & TFF

Innovative Technology

Focusing on the design and development of core products such as fermenters, bioreactors, TFF systems, and membrane separation systems, we are guided by the principle of “empowering industrial upgrading through technological breakthroughs”, integrating multidisciplinary innovation concepts with engineering practice experience. From product structural optimization and fluid dynamics simulation to the development of high-efficiency mass and heat transfer technologies, intelligent control system integration, membrane material adaptation improvements, and precise regulation of tangential flow process parameters—each innovation is is designed to solve industry pain points.

Through continuous technological iteration and experimental testing, HOLVES has overcome the performance limitations of traditional equipment, enhancing product stability, efficiency, and energy savings to provide customers with more competitive equipment technology support.

New Design

HOLVES has redesigned its products based on integrated and modular concepts. By eliminating redundant structures, it enhances performance while ensuring operational safety. The new appearance not only establishes a professional visual identity but also drives deep optimization of internal structures and overall layout.

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Feed-Sup® Feeding System

HOLVES Feed-Sup® Feeding System is specifically designed to enhance the efficiency and yield of cell culture and fermentation processes by achieving precision and automation in the feeding process. Through multiple intelligent control modes, it enables precise regulation by coordinating parameters such as pH and dissolved oxygen (DO), ensuring nutrient supply precisely matches the actual metabolic demands of the microbial cells.

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H-Mix® Mixing System

Agitation is the core function of a bioreactor. HOLVES is designed with the industry's first H-NM® 3D Innovative no machine seal, eliminating the contamination risks and maintenance burdens associated with traditional mechanical seals. Optimized through computational fluid dynamics (CFD), it creates a uniform and gentle mixing environment throughout the entire culture volume.

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Meta-Tri® Audit Trail

Under stringent regulations, data integrity serves as the cornerstone of product quality assurance. The HOLVES audit trail system based on cryptographic modules and an operation log database enables seamless recording of equipment operations throughout their lifecycle and implements tiered permission management, ensuring the integrity and trustworthiness of production data.

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Smart-SC® Sequential Control

HOLVES Intelligent Sequential Control System achieves one-click automation throughout the entire process from inoculation to harvest via multi-stage control of customizable parameters including temperature, pH, stirring, and feed addition. This significantly reduces manual intervention, ensures high batch-to-batch consistency, and supports seamless scale-up from process development to large-scale production.

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Precision Processing

Superior equipment performance begins with precision craftsmanship in every component. HOLVES insists on utilizing advanced machining centers and manufacturing processes to perform high-standard precision machining and treatment on every surface that comes into contact with the product, ensuring exceptional corrosion resistance, easy cleanability, and extended service life.

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Industry Applications

Based on core product strengths including fermenters, bioreactors, TFF systems, and membrane separation systems, HOLVES focus on diverse application scenarios to deliver customized solutions for industries such as biopharmaceuticals, food and beverage, microbial fermentation, environmental water treatment, and new materials.

To meet the process characteristics and production demands of diverse industries, HOLVES establish a comprehensive service system spanning the entire lifecycle—from preliminary process research and solution design planning, through equipment selection and configuration, system integration and commissioning, to post-implementation operational support and technological upgrades. Whether it's high-purity product separation and purification in biopharmaceuticals, efficient fermentation and quality control in food and beverage, or effective pollutant treatment in environmental protection, HOLVES delivers adaptable, cost-effective solutions that help clients optimize production processes, enhance product quality, and reduce operational costs.