Specialized in Cell Culture Process Development
HOLVES Omini Cell510 Series all-purpose Bioreactor, focused on cell culture process development, centers on a stainless steel intelligent platform. It is dedicated to providing standardized solutions that combine high cost-effectiveness with exceptional flexibility for process development, pilot-scale upscaling, and GMP clinical sample production stages.
It deeply integrates forward-thinking design with local lean manufacturing, not only providing stable and reliable process support throughout cell culture via high-precision automation systems, but also leveraging a modular architecture to flexibly adapt to future process pathway expansion and upgrade requirements. From fundamental parameter control to compatibility with complex process scenarios, the Omini Cell510 achieves precise alignment between equipment and processes through highly scalable hardware configurations and intelligent control logic.
Applications
Biopharmaceuticals
Biochemistry
Food Chemical
Cell Culture
Fine Chemical Engineering
Microorganism
HIGHLIGHTS
High Cost Effective
- Long-term economic efficiency with no ongoing consumable costs: Constructed from 316L stainless steel, with material-contact surfaces treated by both mechanical and electrolytic polishing. A single investment ensures decades of reuse, making it the more economical choice for large-scale, commercial production.
- Mature Domestic Platform: Drawing on internationally advanced design concepts and integrating localized manufacturing and services, we ensure stable and reliable equipment performance while offering rapid after-sales response and more competitive pricing.
Flexible Expansion
This equipment supports modular precision configuration, compatible with disposable / traditional systems and aseptic sampling systems. Its 100L scale enables seamless process scale-up, meeting diverse industrialization requirements.
Precision Configuration, On-Demand Selection: Provides diverse modular configuration solutions ranging from basic to full-featured models. Precisely select components based on budget planning and process requirements, ensuring seamless compatibility with single-use systems or traditional stainless steel piping.
Cross-System Compatibility and Adaptability: Supports connection to single-use sterile sampling systems, combining the reliability of stainless steel systems to build diversified upstream solutions that balance cross-contamination risk control with operational flexibility.
Seamless Scale-Up of Critical Support: The 100L scale precisely bridges pilot and production stages. Its meticulously optimized design parameters ensure laboratory processes can be successfully scaled up to production scale, effectively resolving traditional process scaling challenges. This reduces process adjustment costs during scaling and accelerates industrialization.
Security Guarantee
The supply chain for this equipment is independently controlled and capable of withstanding high pressure and demanding agitation. It has undergone multiple rigorous validations to ensure compliance with GMP requirements, guaranteeing safe, stable production and efficient cultivation.
The supply chain is fully controlled: Core materials utilize standard 316L stainless steel, with non-contact liquid components made of 304 stainless steel. Sealing components such as gaskets adopt pharmaceutical-grade polymer materials. The supply chain is completely self-controlled, avoiding material supply risks at the source and establishing a solid foundation for production safety.
Strict Safety Design: Through professional pressure testing, steam sterilization validation (maintaining 121°C high temperature and pressure for 30 minutes), and multiple rigorous verification procedures, it meets GMP stringent requirements for equipment sterility assurance. This ensures structural safety and operational stability during long-term continuous operation, eliminating potential safety hazards.
Better Operating Tolerance: Withstands higher pressures and demanding agitation conditions. Equipped with a low-shear, high-efficiency mixing system optimized using CFD, it provides greater flexibility for process optimization and supports achieving higher cell density cultivation goals.
HF-Control v3.0 Holographic Intelligent Control System
HOLVES 3.0 Holographic Intelligent Control System, which integrates the sense of design and practicability, realizing a leapfrog upgrade.
- Automotive-grade UI Design: The interface adopts a dark theme, with a centralized minimalist design and layered architecture, presenting the complex process data in a more intuitive and multi-dimensional way.
- Dual-screen Synergy: Main screen integrated operation control interface, support multi-level menu view. The bottom of the fixed sub-screen display, the core data visualization area, real-time dynamic display of key parameters trends.
- Safe and Compliant Data Management: It supports data export, has built-in multi-level permission management, requires authorization for critical operations, meets GMP data traceability requirements.
- Multi-Parallel Fermenter Synergy Control: For complex systems such as multi-parallel fermenters and cascade fermenters, it supports one-key switching between single vessel and multi-vessel modes, with a unified operation interface.
Product Display
All-PURPOSE Stainless Steel Bioreactor
| Product model | Omini Cell510-30L | Omini Cell510-50L | Omini Cell510-100L | Omini Cell510-200L | Omini Cell510-300L | Omini Cell510-500L | Omini Cell510-1000L | Omini Cell510-2000L | |
| Vessel volume | 30L | 50L | 100L | 200L | 300L | 500L | 1000L | 2000L | |
| Working volume | 8-24L | 12-40L | 25-80L | 40-160L | 80-240L | 100-400L | 200-800L | 400-1600L | |
| Material (inner) | inner vessel: AISI 316L stainless steel mirror polishing | ||||||||
| Material (outer) | vessel outer wall and jacket: AISI 304 stainless steel | ||||||||
| Manufacturing STD | ASME BPE-2019, PED certification standards | ||||||||
| Polishing | product contact: mechanical polish to Ra≤0.4µm | ||||||||
| Stirring power | Leadshine, PID control | ||||||||
| Stirring speed | 20-800±1 | 20-400±1 | 20-300±1 | ||||||
| Stirring impeller | Propeller type stirrer / Rotary Filter / Basket Impeller / Up-pumping Impeller | ||||||||
| Temperature control | PT100, PID control, Temperature regulation is accomplished by plate heat exchangers/ electrically heated jackets and cooling water. | ||||||||
| Heating form | Temperature control jacket | ||||||||
| Temperature range | Ambient temperature above 5-60℃, measuring range 0-150℃, accuracy ±0.1℃, resolution 0.01 | ||||||||
| pH | 0-14, precision ±0.02, resolution 0.01, PID control, Done under the control of acid / base pumps or CO2 mass flow meters | ||||||||
| DO | 0-100% O2 Saturation, precision ≤±(1%+6ppb), resolution 0.01, PID control | ||||||||
| Aeration method | Surface aeration | ||||||||
| Filter | Pre-filtration 0.2μm, Fine filtration 0.01μm, PTEF, Optional: heated jacket for the exhaust filter housing | ||||||||
| Exhaust condenser | AISI 316L / AISI 304L stainless steel | ||||||||
| Peristaltic pump | Standard 4 units, PID interlocking control, foam / feed / acid / base, feed can be added | ||||||||
| Interfaces |
Inlet/Outlet Ports: inoculation valve ports, feed valve ports, online sampling ports, PAT spare interfaces, bottom valves, surface vents, deep vents, safety rupture discs/pressure relief valves. Probe Interfaces: Dedicated ports for monitoring pH, DO, level, pressure, foam, and other parameters. Operational status visualization windows and searchlights. Supports customization |
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Automatic high-pressure steam sterilization Standard |
Automatic Lid Lifting Standard |
Automatic Vessel Pressure Standard |
The Integrated Vessel Bottom Valve Standard |
CIP Automatic Cleaning Option |
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Multiple Vessel Modular Expansion Option |
Vessel Weighing Module Option |
Feeding Weighing Module Option |
PAT Process Detection Extension Option |
Support Customized Functions Option |
Product Brochure
Product Brochure
Detailed parameters
HOLVES Omini Cell510 Series All-purpose Bioreactor (Cell culture vessel) delivers integrated advantages of ‘more stable, more flexible, and more reliable,’ making it the ideal intelligent partner for cell culture processes from development to scale-up.
