GLP-1 Drug Preparation

Currently, industrial production of GLP-1 analog drugs primarily relies on two major technologies: microbial fermentation (biosynthetic method) and chemical synthesis. However, several new synthetic processes are also emerging. Among these, microbial fermentation is the mainstream production method for the vast majority of currently marketed GLP-1 drugs (such as semaglutide, liraglutide, dulaglutide, etc.). Chemical synthesis is also applied to certain short peptides or GLP-1 drugs with specific structures. Both methods possess distinct advantages and are not mutually exclusive, yet chemical synthesis remains particularly crucial for research and early development stages.